HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → 3,5-diamino-1-methyl-1H-pyrazole-4-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3,5-Diamino-1H-pyrazole-4-carbonitrile | HCID 14202141 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 3,5-diamino-1-methyl-1H-pyrazole-4-carbonitrile | HCID 12621028 | 16.2% |
Reaction Steps
3,5-Diamino-4-cyanopyrazole (6.1 g) prepared as in Example 3, iodomethane (3.1 ml), anhydrous potassium carbonate (7.6 g) and acetone (120 ml) were heated under reflux for 18 hours. The mixture was filtered, and the filtrate was concentrated to a viscous oil. Trituration of the oil with water gave a precipitate of 3,5-diamino-4-cyano-1-methylpyrazole (1.1 g), m.p. 194°-196° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04163846 |
| Source dataset | uspto-grants-1979_08 |
| ORD ID | ord-027954cc5b4a46fdabac1c15a9c3705b |
| Source note | uspto-grants-1979_08 |