反应详情

3,5-Diamino-4-cyanopyrazole (6.1 g) was dissolved in 1 M sodium hydroxide solution (50 ml), and dimethylsulphate (6.2 g) was added. The mixture was heated at reflux for 21/2 hours and then evaporated to dryness. The residue was extracted with 2-methoxyethanol, and the extracts were evaporated. The residue was triturated with a small amount of water to give 3,5-diamino-4-cyano-1-methylpyrazole (1.4 g), m.p. 194°-196° C.

1. temperatureThe mixture was heated
2. temperatureat reflux for 21/2 hours
3. customevaporated to dryness
4. extractionThe residue was extracted with 2-methoxyethanol
5. customthe extracts were evaporated
6. customThe residue was triturated with a small amount of water