反应详情

To a stirred suspension of 114 g (0.69 mole) of β-amino-β-(3-pyridyl)propionic acid in 2,850 ml of ethanol was added a 5° C. solution of 417 g of sulfuric acid in 240 ml of ethanol. After stirring for 1 hour, the resultant clear solution was left standing at room temperature for 48 hours and then concentrated to incipient crystallization in vacuum at a temperature below 50° C. The solution was added to a suspension of 715 g of sodium bicarbonate in 1430 ml of water over 1 hour. The temperature of the solution was maintained between 0° to 5° C. After stirring an additional 30 minutes, 300 ml of carbon tetrachloride was added and the admixture stirred for 10 minutes. The by-product salt was removed by filtration and the aqueous layer was extracted thoroughly with carbon tetrachloride. The combined organic extracts were dried and concentrated under vacuum to yield 87.11 g (65% yield) of crude ethyl β-amino-β-(3-pyridyl)propionate as a slightly viscous green liquid.

1. waitthe resultant clear solution was left
2. waitstanding at room temperature for 48 hours
3. concentrationconcentrated
4. customcrystallization in vacuum at a temperature below 50° C
5. additionThe solution was added to a suspension of 715 g of sodium bicarbonate in 1430 ml of water over 1 hour
6. temperatureThe temperature of the solution was maintained between 0° to 5° C
7. stirringAfter stirring an additional 30 minutes
8. addition300 ml of carbon tetrachloride was added
9. stirringthe admixture stirred for 10 minutes
10. customThe by-product salt was removed by filtration
11. extractionthe aqueous layer was extracted thoroughly with carbon tetrachloride
12. customThe combined organic extracts were dried
13. concentrationconcentrated under vacuum