Dimethylamine → HCID 23349433, compound

HRID 261136Notes

Reaction equation

HRID 261136 reaction equation
[Br:1][CH2:2][C:3]1[CH:8]=[C:7]([Cl:9])[CH:6]=[CH:5][C:4]=1[N:10]=[C:11]=[O:12].[CH3:13][NH:14][CH3:15]>C1(C)C=CC=CC=1>[BrH:1].[Cl:9][C:7]1[CH:6]=[CH:5][C:4]2[N:10]=[C:11]([N:14]([CH3:15])[CH3:13])[O:12][CH2:2][C:3]=2[CH:8]=1

Participants

4

Reactant 2

HCID 674DimethylamineHCID 23349415HCID 23349415, compound

Product 1

HCID 23349433HCID 23349433, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Procedure

2 g (0.008 M) of 2-bromomethyl-4-chlorophenylisocyanate is dissolved in 50 ml. of toluene. To the solution in a reaction vessel, is slowly added 0.36 g (0.008 M) of dimethylamine in 20 ml of toluene with stirring; maintaining the temperature of from 35° to 40° (over a period of about 6 hours) resulting in the separation of the crude title product as the hydrobromide acid addition salt, which may be recovered and refined by washing with diethyl ether m.p. 183°-186°.

Workup

  1. customTo the solution in a reaction vessel, is slowly added
  2. temperaturemaintaining the temperature of from 35° to 40° (over a period of about 6 hours)

Sources & evidence

ORD record
ord-f5f6c13274674d2e99d2916023304e05
Source dataset
uspto-grants-1979_08
Patent number
US04164407

Reaction notes

Loading…