HCID 20329347, compound → HCID 20329299, compound

HRID 261172Notes

Reaction equation

HRID 261172 reaction equation
[N+:1]([C:4]1[CH:22]=[CH:21][C:7]2[NH:8][C:9](=[O:20])[CH2:10][C:11](=[O:19])[N:12]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[C:6]=2[CH:5]=1)([O-])=O.[H][H]>C(O)C.[Ni]>[NH2:1][C:4]1[CH:22]=[CH:21][C:7]2[NH:8][C:9](=[O:20])[CH2:10][C:11](=[O:19])[N:12]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[C:6]=2[CH:5]=1

Participants

5

Reactant 2

HCID 20329347HCID 20329347, compoundHCID 178418361HCID 178418361, compound2×

Product 1

HCID 20329299HCID 20329299, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

29.7 g of 7-nitro-5-phenyl-1H-1,5-benzodiazepine-2,4-dione in 200 ml ethanol containing 1.0 g of Raney nickel is hydrogenated at room temperature at an initial hydrogen pressure of 50 p.s.i. The reaction is stopped after 0.3 moles of hydrogen has been absorbed. The reaction mixture is filtered and the filtrate evaporated to give 7-amino-5-phenyl-3H-1,5-benzodiazepine-2,4-dione.

Workup

  1. customhas been absorbed
  2. filtrationThe reaction mixture is filtered
  3. customthe filtrate evaporated

Sources & evidence

ORD record
ord-324b3a26f2ef41388092f4d757c81053
Source dataset
uspto-grants-1979_08
Patent number
US04164498

Reaction notes

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