HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloromethyl ethyl ketone → 4-Ethyl-4-hydroxy-3-(6-methylpyrid-2-yl)-thiazolidine-2-thione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloromethyl ethyl ketone | HCID 69219 | — |
| Reactant | Triethylammonium 6-methylpyrid-2-yldithiocarbamate | HCID 20393055 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-Ethyl-4-hydroxy-3-(6-methylpyrid-2-yl)-thiazolidine-2-thione | HCID 20393073 | 71.1% |
Reaction Steps
The procedure of Example 1 is followed but starting with triethylammonium (6-methylpyrid-2-yl)dithiocarbamate (71.0 g) and 1-chlorobutan-2-one (26.6 g) in distilled water (300 cc) at 20° C. The reaction is carried out for 3 hours at 20° C. After recrystallisation of the product from ethanol (250 cc), there is obtained 4-ethyl-4-hydroxy-3-(6-methylpyrid-2-yl)-thiazolidine-2-thione (45.0 g) melting at 118° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04164579 |
| Source dataset | uspto-grants-1979_08 |
| ORD ID | ord-57b0ed6328d549958ab32c2b16a5e60c |
| Source note | uspto-grants-1979_08 |