反应详情

The procedure of Example 4 is followed but starting with triethylammonium (6-methylpyrid-2-yl)dithiocarbamate (28.5 g) and 1-chloro-4-methylpentan-2-one (13.4 g) in anhydrous acetonitrile (200 cc) at a temperature between 20 and 25° C. The reaction is continued for 2 hours at 20°-25° C. After recrystallisation of the product from diisopropyl ether (390 cc) and filtration of the boiling solution, there is obtained 4-hydroxy-4-isobutyl-3-(6-methylpyrid-2-yl)-thiazolidine-2-thione (16.8 g) melting at 95° C.

1. customAfter recrystallisation of the product
2. filtrationfrom diisopropyl ether (390 cc) and filtration of the boiling solution