Trifluoroacetic acid → Ether hydrochloride

Participants

Reaction Steps

A solution of 14 g of 6-chloro-3a,4,9,9a-tetrahydro-2,4-dimethylbenz[f]isoindolin-4-ol in 140 ml of trifluoro-acetic acid is stirred for one hour at room temperature and then evaporated. The residue is taken up in ice cold aqueous sodium hydroxide solution, extracted with methylene chloride, the organic phase dried over sodium sulphate and the solution evaporated. The title compound is obtained by crystallisation from methanolic hydrochloric acid/ether. M.P. 253°-255° (Hydrochloride salt form).

Provenance & Evidence