Acetic Acid → HCID 20329336, compound

HRID 261227Notes

Reaction equation

HRID 261227 reaction equation
C([O:4][CH:5]1[C:11](=[O:12])[N:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:9]2[CH:19]=[C:20]([Cl:23])[CH:21]=[CH:22][C:8]=2[N:7]2[CH:24]=[N:25][N:26]=[C:6]12)(=O)C.[OH-].[Na+].C(O)(=O)C>C(O)C>[OH:4][CH:5]1[C:11](=[O:12])[N:10]([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[C:9]2[CH:19]=[C:20]([Cl:23])[CH:21]=[CH:22][C:8]=2[N:7]2[CH:24]=[N:25][N:26]=[C:6]12

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 14798Sodium HydroxideHCID 20395211HCID 20395211, compound

Product 1

HCID 20329336HCID 20329336, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

3.5 g of 4-acetoxy-8-chloro-6-phenyl-4H-s-triazolo[4,3-a][1,5]benzodiazepin-5-one and 2.8 ml of 4 N aqueous sodium hydroxide in 160 ml of ethanol are stirred overnight at 25°. The reaction is neutralized with 0.5 g of acetic acid and the solvent is evaporated. The residue is partitioned between chloroform and water, the organic phase is dried and the solvent evaporated to give the title compound.

Workup

  1. customthe solvent is evaporated
  2. customThe residue is partitioned between chloroform and water
  3. customthe organic phase is dried
  4. customthe solvent evaporated

Sources & evidence

ORD record
ord-35e7514c20c6484f8409a097d863459c
Source dataset
uspto-grants-1979_08
Patent number
US04164580

Reaction notes

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