HCID 20329298, compound → HCID 20329311, compound

HRID 261232Notes

Reaction equation

HRID 261232 reaction equation
[CH3:1][C:2]1[N:6]2[C:7]3[CH:22]=[CH:21][C:20]([N+:23]([O-])=O)=[CH:19][C:8]=3[N:9]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[C:10](=[O:12])[CH2:11][C:5]2=[N:4][N:3]=1.[H][H]>C(O)C.[Ni]>[CH3:1][C:2]1[N:6]2[C:7]3[CH:22]=[CH:21][C:20]([NH2:23])=[CH:19][C:8]=3[N:9]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[C:10](=[O:12])[CH2:11][C:5]2=[N:4][N:3]=1

Participants

5

Reactant 2

HCID 20329298HCID 20329298, compoundHCID 178418361HCID 178418361, compound2×

Product 1

HCID 20329311HCID 20329311, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

33.5 g of 1-methyl-8-nitro-6-phenyl-4H-s-triazolo[4,3-a][1,5]benzodiazepin-5-one in 100 ml of ethanol containing 2.0 g of Raney nickel is hydrogenated at room temperature at an initial hydrogen pressure of 50 p.s.i. The reaction is stopped when 0.3 moles of hydrogen has been absorbed; the suspension is filtered and the filtrate evaporated to give the title compound.

Workup

  1. customhas been absorbed
  2. filtrationthe suspension is filtered
  3. customthe filtrate evaporated

Sources & evidence

ORD record
ord-f4cb3d45baf54777b8fd19be5836f7fc
Source dataset
uspto-grants-1979_08
Patent number
US04164580

Reaction notes

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