Acetic Anhydride → HCID 20329339, compound

HRID 261233Notes

Reaction equation

HRID 261233 reaction equation
[CH3:1][C:2]1[N:6]2[C:7]3[CH:22]=[CH:21][C:20]([NH2:23])=[CH:19][C:8]=3[N:9]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[C:10](=[O:12])[CH2:11][C:5]2=[N:4][N:3]=1.[C:24](OC(=O)C)(=[O:26])[CH3:25]>N1C=CC=CC=1>[CH3:1][C:2]1[N:6]2[C:7]3[CH:22]=[CH:21][C:20]([NH:23][C:24](=[O:26])[CH3:25])=[CH:19][C:8]=3[N:9]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[C:10](=[O:12])[CH2:11][C:5]2=[N:4][N:3]=1

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 20329311HCID 20329311, compound

Product 1

HCID 20329339HCID 20329339, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

3.47 g of 1-methyl-8-amino-6-phenyl-4H-s-triazolo[4,3-a][1,5]benzodiazepin-5-one and 1.02 g of acetic anhydride in 50 ml pyridine is stirred for 12 hours then refluxed for 30 minutes. The reaction is evaporated; the residue is taken up in chloroform, washed with dilute aqueous sodium bicarbonate, with water and dried. The solvent is evaporated to give the title compound.

Workup

  1. temperaturethen refluxed for 30 minutes
  2. customThe reaction is evaporated
  3. washwashed with dilute aqueous sodium bicarbonate, with water
  4. customdried
  5. customThe solvent is evaporated

Sources & evidence

ORD record
ord-ed9f2a8de994444a9608533be2e57521
Source dataset
uspto-grants-1979_08
Patent number
US04164580

Reaction notes

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