HCID 20329343, compound → HCID 20329304, compound

HRID 261234Notes

Reaction equation

HRID 261234 reaction equation
C([O:8][CH:9]1[C:15](=[O:16])[N:14]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:13]2[CH:23]=[C:24]([Cl:27])[CH:25]=[CH:26][C:12]=2[N:11]2[C:28]([CH3:31])=[N:29][N:30]=[C:10]12)C1C=CC=CC=1.[H][H]>C(O)C.[Ni]>[OH:8][CH:9]1[C:15](=[O:16])[N:14]([C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[C:13]2[CH:23]=[C:24]([Cl:27])[CH:25]=[CH:26][C:12]=2[N:11]2[C:28]([CH3:31])=[N:29][N:30]=[C:10]12

Participants

5

Reactant 2

HCID 20329343HCID 20329343, compoundHCID 178418361HCID 178418361, compound2×

Product 1

HCID 20329304HCID 20329304, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

44.6 g of 4-(benzyloxy)-1-methyl-8-chloro-6-phenyl-4H-s-triazolo[4,3-a][1,5]benzodiazepin-5-one in 400 ml of ethanol containing 2.0 g of Raney nickel is hydrogenated at an initial hydrogen pressure of 40 p.s.i. After 0.1 mole of hydrogen has been absorbed, the reaction is stopped, filtered and the solvent evaporated. The residue is triturated in ether and the title compound filtered off and dried.

Workup

  1. filtrationfiltered
  2. customthe solvent evaporated
  3. customThe residue is triturated in ether
  4. filtrationthe title compound filtered off
  5. customdried

Sources & evidence

ORD record
ord-ef27e10aca8d4c51b5d8f60658fd8673
Source dataset
uspto-grants-1979_08
Patent number
US04164580

Reaction notes

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