HCID 20329307, compound → HCID 70609086, compound

HRID 261237Notes

Reaction equation

HRID 261237 reaction equation
[CH2:1]([N:8]([CH2:10][CH2:11][CH:12]1[C:18](=[O:19])[N:17]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:16]2[CH:26]=[C:27]([Cl:30])[CH:28]=[CH:29][C:15]=2[N:14]2[C:31]([CH3:34])=[N:32][N:33]=[C:13]12)C)C1C=CC=CC=1.[H][H]>C(O)C.[Ni]>[CH3:1][NH:8][CH2:10][CH2:11][CH:12]1[C:18](=[O:19])[N:17]([C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[C:16]2[CH:26]=[C:27]([Cl:30])[CH:28]=[CH:29][C:15]=2[N:14]2[C:31]([CH3:34])=[N:32][N:33]=[C:13]12

Participants

5

Reactant 2

HCID 20329307HCID 20329307, compoundHCID 178418361HCID 178418361, compound2×

Product 1

HCID 70609086HCID 70609086, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

4 g of 4-[2-(N-benzyl-N-methylamino)ethyl]-1-methyl-8-chloro-6-phenyl-4H-s-triazolo[4,3-a][1,5]benzodiazepin-5-one in 100 ml of ethanol containing 0.4 of Raney nickel is hydrogenated at 50 p.s.i. hydrogen pressure until 0.0085 moles of hydrogen is absorbed. The suspension is filtered and the filtrate is evaporated. The residue is triturated with a small amount of cold ether and the title compound is filtered off and dried.

Workup

  1. filtrationThe suspension is filtered
  2. customthe filtrate is evaporated
  3. customThe residue is triturated with a small amount of cold ether
  4. filtrationthe title compound is filtered off
  5. customdried

Sources & evidence

ORD record
ord-fda71309771b4b2d8dc94d9ea1dfa76d
Source dataset
uspto-grants-1979_08
Patent number
US04164580

Reaction notes

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