Hydrazine hydrate (1:1) → 4-Hydroxy-3,5-dimethylbenzene-1-sulfonohydrazide

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Reaction Steps

15.0 g (0.3 mol) of hydrazine hydrate are first introduced into 60 ml of dimethylacetamide. 22 g (0.1 mol) of 3,5-dimethyl-4-hydroxybenzenesulfonic acid chloride dissolved in 60 ml of dioxane are added dropwise to this solution over the course of 15 minutes. This causes the temperature to rise to 90° C., at which level it is maintained by slight cooling. The mixture is allowed to react for a further 90 minutes and is then completely concentrated under reduced pressure. The residue is recrystallised first from a little water and then from isopropanol. This gives 3,5-dimethyl-4-hydroxybenzenesulphonic acid hydrazide, which melts at 186° C. (with decomposition).

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