HCID 70593999, compound → HCID 70590563, compound

HRID 261253Notes

Reaction equation

HRID 261253 reaction equation
Br[CH2:2][C:3]1([CH3:35])[CH:7]([C:8]([O:10][CH2:11][C:12]([Cl:15])([Cl:14])[Cl:13])=[O:9])[N:6]2[C:16](=[O:34])[CH:17]([NH:18][C:19]([C:21]3[C:22]([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=4[Cl:33])=[N:23][O:24][C:25]=3[CH3:26])=[O:20])[C@H:5]2[S:4]1.[CH3:36][N:37]1[C:41]([SH:42])=[N:40][N:39]=[N:38]1>P([O-])([O-])([O-])=O.CC(C)=O>[CH3:36][N:37]1[C:41]([S:42][CH2:2][C:3]2([CH3:35])[CH:7]([C:8]([O:10][CH2:11][C:12]([Cl:15])([Cl:14])[Cl:13])=[O:9])[N:6]3[C:16](=[O:34])[CH:17]([NH:18][C:19]([C:21]4[C:22]([C:27]5[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=5[Cl:33])=[N:23][O:24][C:25]=4[CH3:26])=[O:20])[C@H:5]3[S:4]2)=[N:40][N:39]=[N:38]1

Participants

5

Reactant 2

HCID 70593999HCID 70593999, compoundHCID 178482017HCID 178482017, compound

Product 1

HCID 70590563HCID 70590563, compound

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 1061PhosphateSolvent

Procedure

By treating in the similar manner as described in Example 11 using 2,2,2-trichloroethyl 2-bromomethyl-2-methyl-6-[3-(2-chlorophenyl)-5-methylisoxazole-4-carboxamido]penam-3-carboxylate and 1-methyl-IH-tetrazole-5-thiol in a mixture of pH 6.85 phosphate buffer and acetone, there was obtained amorphous 2,2,2-trichloroethyl 2-(1-methyl-IH-tetrazol-5-yl)thiomethyl-2methyl-6-[3-(2-chlorophenyl)-5-methylisoxazole-4-carboxamido]penam-3-carboxylate.

Workup

  1. additionBy treating in the similar manner

Sources & evidence

ORD record
ord-93226ab9312541d8a859103eb91c82b5
Source dataset
uspto-grants-1979_08
Patent number
US04164497

Reaction notes

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