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Triethylamine → HCID 178525480、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 3-Chloro-1,2-benzisothiazole | HCID 598190 | — |
| 反応物 | 4-Aminobutyrate ethyl hydrochloride | HCID 12649661 | — |
| 反応物 | HCID 178471604 | HCID 178471604 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | HCID 178525480 | HCID 178525480 | — |
反応手順
5.68 g. (28.1 mM) of 3-chloro-1,2-benzisothiazole, 1,1-dioxide (prepared as in Example 1), 4.8 g. (28.1 mM) of ethyl-4-aminobutyrate hydrochloride and 7.84 ml. (56.2 mM) of triethylamine are refluxed in 100 ml. of dioxane for one hour. The solvent is evaporated and the residue refluxed in 1% hydrochloric acid for 2.5 hours. The product crystallizes out overnight at room temperature. The product, 4-[(1,1-dioxo-1,2-benzisothiazol-3-yl)amino]butanoic acid is filtered out, washed with water, and recrystallized from 150 ml. water, yield 4.2 g., m.p. 200°-202°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04148798 |
| 出典データセット | uspto-grants-1979_04 |
| ORD ID | ord-82fb8dd1b25a4ee5817020472937d49b |
| 出典メモ | uspto-grants-1979_04 |