HCID 12531249, compound → HCID 53875341, compound

Participants

Reaction Steps

A solution of 1.2 g. (0.005 mol) of N-(2-carboxy-2-oxoacetyl)-3-nitroaniline in 60 ml. of methanol was hydrogenated over 200 mg. of 10% palladium-on-carbon at 50 psi. When the theoretical amount of hydrogen had been absorbed the reduction was stopped, 40 ml. of 5% aqueous sodium bicarbonate solution was added and the catalyst filtered. The filtrate was evaporated to approximately 50 ml., acidified with 3N hydrochloric acid to pH 2 and the resulting precipitate filtered, washed with water and dried to give N-(2-carboxy-2-oxoacetyl)-1,3-phenylene diamine, m.p. 246° C.

Provenance & Evidence