Sodium Iodide → 1-Iodooct-1-en-3-one

HRID 261382노트

반응식

HRID 261382 반응식
Cl[CH:2]=[CH:3][C:4](=[O:10])[CH2:5][CH2:6][CH2:7][CH2:8][CH3:9].[I-:11].[Na+]>CC(C)=O>[I:11][CH:2]=[CH:3][C:4](=[O:10])[CH2:5][CH2:6][CH2:7][CH2:8][CH3:9]

참가 물질

4

반응물 2

HCID 5238Sodium IodideHCID 545149151-Chloro-1-octen-3-one

생성물 1

HCID 534008741-Iodooct-1-en-3-one수율 64.5%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 25 g (0.16 moles) of 1-chloro-1-octen-3-one (Example 187) and 35 g (0.23 moles) of sodium iodide in 200 ml of reagent acetone is stirred at the reflux temperature for 18 hours. The cooled mixture is filtered and the mother liquor taken to dryness. The residual oil is dissolved in benzene and the solution is washed with 5% sodium thiosulfate solution, saturated sodium chloride solution, dried and taken to dryness. The residual oil is crystallized from hexane to give 26 g of a white solid, mp 35°-37° C.; λ max 1670, 950 cm-1.

후처리

  1. filtrationThe cooled mixture is filtered
  2. dissolutionThe residual oil is dissolved in benzene
  3. washthe solution is washed with 5% sodium thiosulfate solution, saturated sodium chloride solution
  4. customdried
  5. customThe residual oil is crystallized from hexane

출처 및 근거

ORD 기록
ord-01c8c142a13a405ab0f953c23b1575fe
출처 데이터셋
uspto-grants-1979_08
특허 번호
US04165331

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