1,3-Dichloroacetone → HCID 86736622, compound

HRID 261420Notes

Reaction equation

HRID 261420 reaction equation
[Cl:1][CH2:2][C:3]([CH2:5]Cl)=O.[CH2:7]([NH:11][C:12]([NH:14][C:15]([NH2:17])=[S:16])=[NH:13])[CH2:8][CH2:9][CH3:10]>CC(C)=O>[ClH:1].[CH2:7]([N:11]=[C:12]([NH2:13])[NH:14][C:15]1[S:16][CH:5]=[C:3]([CH2:2][Cl:1])[N:17]=1)[CH2:8][CH2:9][CH3:10]

Participants

4

Reactant 2

HCID 107931,3-DichloroacetoneHCID 178449223HCID 178449223, compound

Product 1

HCID 86736622HCID 86736622, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent2×

Procedure

A solution of 1,3-dichloroacetone (3.02 g.) in acetone (10 ml.) was added to a stirred suspension of (N-n-butylamidino)thiourea (4.04 g.) in acetone (25 ml.) at room temperature. The resulting clear pale yellow solution was stirred for three days, then cooled in ice, and the precipitated solid filtered off and washed with acetone to give 2-(2-n-butylguanidino)-4-chloromethylthiazole hydrochloride

Workup

  1. temperaturecooled in ice
  2. filtrationthe precipitated solid filtered off
  3. washwashed with acetone

Sources & evidence

ORD record
ord-f57012f113c043f4905353d7c9626250
Source dataset
uspto-grants-1979_08
Patent number
US04165378

Reaction notes

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