Methyl iodide → HCID 178441424, compound

HRID 261428Notes

Reaction equation

HRID 261428 reaction equation
[NH:1]([C:5]1[S:6][CH:7]=[C:8]([CH2:10][CH2:11][CH2:12][CH2:13]NC(NC)=S)[N:9]=1)[C:2]([NH2:4])=[NH:3].[C:19]([OH:26])(=[O:25])/[CH:20]=[CH:21]\[C:22]([OH:24])=[O:23].C[I:28]>C(O)C>[IH:28].[C:19]([OH:26])(=[O:25])/[CH:20]=[CH:21]\[C:22]([OH:24])=[O:23].[NH:1]([C:5]1[S:6][CH:7]=[C:8]([CH2:10][CH:11]([NH:9][C:5](=[N:1][CH3:2])[S:6][CH3:7])[CH2:12][CH3:13])[N:9]=1)[C:2]([NH2:4])=[NH:3]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 444266Maleic AcidHCID 178486110HCID 178486110, compound

Product 1

HCID 178441424HCID 178441424, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 2-guanidino-4-[4-(3-methylthioureido)butyl]thiazole in ethanol (15 ml.) is treated with the appropriate amount of maleic acid to give a solution containing 0.42 g. of the hydrogen maleate salt. This solution is treated with methyl iodide (0.17 g.) and the mixture heated under reflux for 1.5 hours. Concentration of the reaction mixture to 5 ml. and collection of the precipitated solid gives 2-guanidino-4-[2-(2,3-dimethylisothioureido)butyl]thiazole hydrogen maleate hydriodide.

Workup

  1. customto give a solution
  2. additioncontaining 0.42 g
  3. temperaturethe mixture heated
  4. temperatureunder reflux for 1.5 hours
  5. customand collection of the precipitated solid

Sources & evidence

ORD record
ord-6292dc4906c84d23a17de6af45cd9afc
Source dataset
uspto-grants-1979_08
Patent number
US04165377

Reaction notes

Loading…