反应详情

A mixture of 2-guanidino-4-(4-aminobutyl)thiazole (0.43 g.) and 1,1-di(methylthio)-2-nitroethylene (0.33 g.) in acetonitrile (15 ml.) was heated under reflux for 1 hour. The mixture evaporated to dryness and 33% w/v ethanolic methylamine (200 ml.) added. The mixture was stirred for 5 days at room temperature, then filtered and the filtrate evaporated to dryness. The residue was crystallized from ethanol to give 1-[4-(2-guanidinothiazol-4-yl)butylamino]-1-methylamino-2-nitroethylene, m.p. 225° C. (decomposed).

1. temperaturewas heated
2. temperatureunder reflux for 1 hour
3. customThe mixture evaporated to dryness and 33%
4. additionadded
5. filtrationfiltered
6. customthe filtrate evaporated to dryness
7. customThe residue was crystallized from ethanol