2-Guanidino-4-(5-aminopentyl)thiazole hydrochloride hydrobromide → HCID 178503914, compound

HRID 261440Notes

Reaction equation

HRID 261440 reaction equation
Br.Cl.[NH:3]([C:7]1[S:8][CH:9]=[C:10]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][NH2:17])[N:11]=1)[C:4]([NH2:6])=[NH:5]>[OH-].[Na+]>[NH:3]([C:7]1[S:8][CH:9]=[C:10]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][NH:17][C:7](=[N:3][C:4]#[N:5])[S:8][CH3:9])[N:11]=1)[C:4]([NH2:6])=[NH:5]

Participants

3

Reactant 1

HCID 1784195802-Guanidino-4-(5-aminopentyl)thiazole hydrochloride hydrobromide

Product 1

HCID 178503914HCID 178503914, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

To 2-guanidino-4-(5-aminopentyl)thiazole hydrochloride hydrobromide (1.2 g.) was added dilute aqueous sodium hydroxide solution (10 ml.). The mixture was stirred briefly, and the white precipitate (0.588 g.) filtered off. This material was dissolved in ethanol (10 ml.) and dimethyl (cyanoimido)dithiocarbonate (0.4 g.) added. The mixture was stirred 2.5 hours to give a solution of 2-guanidino-4-[5-(3-cyano-2-methylisothioureido)pentyl]thiazole.

Workup

  1. filtrationthe white precipitate (0.588 g.) filtered off
  2. dissolutionThis material was dissolved in ethanol (10 ml.)
  3. additiondimethyl (cyanoimido)dithiocarbonate (0.4 g.) added
  4. stirringThe mixture was stirred 2.5 hours

Sources & evidence

ORD record
ord-eed200683136405d8dd1802dc3d741e8
Source dataset
uspto-grants-1979_08
Patent number
US04165377

Reaction notes

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