反应详情

To a solution of 2-guanidino-4-(4-aminobutyl)thiazole (0.426 g.) in ethanol (10 ml.) was added 2-methyl-1-nitroisothiourea (0.270 g.). The mixture was heated under reflux for 4 hours, allowed to cool to room temperature, evaporated to dryness and the residue triturated with alcohol. The product was filtered off and dried to give 2-guanidino-4-[4-(2-nitroguanidino)butyl]thiazole, m.p. 180°-181° C.

1. temperatureThe mixture was heated
2. temperatureunder reflux for 4 hours
3. customevaporated to dryness
4. customthe residue triturated with alcohol
5. filtrationThe product was filtered off
6. customdried