反应详情

A stirred solution of 15 g of 2-(3-dimethylaminopropoxy)benzaldehyde and 10.2 g of glycine, ethyl ester, hydrochloride in 300 ml of ethanol is treated with 4.8 g of 85% potassium hydroxide and stirring continued for 3 hours at room temperature. Potassium chloride is filtered off, washed with ethanol, and the solvent is removed on a rotary evaporator (water bath temperature, 30°-35° C.). The residue is dissolved in ether, filtered, and the evaporation repeated to give 20.9 g of an oil. The material is stored in the cold.

1. filtrationPotassium chloride is filtered off
2. washwashed with ethanol
3. customthe solvent is removed on a rotary evaporator (water bath temperature, 30°-35° C.)
4. dissolutionThe residue is dissolved in ether
5. filtrationfiltered
6. customthe evaporation