Potassium Hydroxide → HCID 12878607, compound

HRID 261461Notes

Reaction equation

HRID 261461 reaction equation
[CH3:1][N:2]([CH3:15])[CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:14]=[CH:13][CH:12]=[CH:11][C:8]=1[CH:9]=O.Cl.[NH2:17][CH2:18][C:19]([NH2:21])=[O:20].[OH-].[K+]>C(O)C>[CH3:1][N:2]([CH3:15])[CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:14]=[CH:13][CH:12]=[CH:11][C:8]=1[CH:9]=[N:17][CH2:18][C:19]([NH2:21])=[O:20]

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 2723639Glycinamide hydrochlorideHCID 29959682-[3-(Dimethylamino)propoxy]benzaldehyde

Product 1

HCID 12878607HCID 12878607, compoundYield 93.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Fifteen grams of 2-(3-dimethylaminopropoxy)benzaldehyde and 8.1 g of glycinamide, hydrochloride are reacted in 300 ml of ethanol in the presence of 4.8 g of 85% potassium hydroxide as described in Example 1 to give 20 g of a crude semi-solid product. The crude product is triturated with 100 ml of isopropyl ether and cooled to yield 17.9 g of solid; melting point 71°-73° C. (sintering at 60° C.).

Workup

  1. customto give 20 g of a crude semi-solid product
  2. customThe crude product is triturated with 100 ml of isopropyl ether
  3. temperaturecooled

Sources & evidence

ORD record
ord-6ae108721e33408c97d8257627040416
Source dataset
uspto-grants-1979_08
Patent number
US04166072

Reaction notes

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