HCID 131711134, compound → HCID 131711132, compound

HRID 261463Notes

Reaction equation

HRID 261463 reaction equation
[C:1]([OH:6])(=[O:5])[C:2]([NH2:4])=[O:3].[CH3:7][N:8]([CH3:40])[CH2:9][CH2:10][CH2:11][O:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[CH2:19][N:20]([CH2:34][C:35]([O:37][CH2:38][CH3:39])=[O:36])[C:21](=[O:33])[CH:22]=[CH:23][C:24]1[CH:29]=[CH:28][C:27]([N+:30]([O-])=O)=[CH:26][CH:25]=1.[H][H]>C(O)C.[Pd]>[C:1]([OH:6])(=[O:5])[C:2]([NH2:4])=[O:3].[CH3:40][N:8]([CH3:7])[CH2:9][CH2:10][CH2:11][O:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[CH2:19][N:20]([CH2:34][C:35]([O:37][CH2:38][CH3:39])=[O:36])[C:21](=[O:33])[CH:22]=[CH:23][C:24]1[CH:25]=[CH:26][C:27]([NH2:30])=[CH:28][CH:29]=1

Participants

5

Reactant 2

HCID 131711134HCID 131711134, compoundHCID 178418361HCID 178418361, compound2×

Product 1

HCID 131711132HCID 131711132, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A suspension of 10 parts of [[[2-[3-(dimethylamino)propoxy]phenyl]methyl][1-oxo-3-(4-nitrophenyl)-2-propenyl]amino]acetic acid, ethyl ester, oxamate salt (1:2) in 100 ml of ethanol is treated with 1 part of 5% palladium on carbon and placed under 3 atmospheres of gaseous hydrogen. The mixture is shaken until one equivalent of hydrogen is consumed, filtered and the solvent evaporated under reduced pressure to give the title compound.

Workup

  1. customis consumed
  2. filtrationfiltered
  3. customthe solvent evaporated under reduced pressure

Sources & evidence

ORD record
ord-608ab8bba96e4d928b7a4839d95a5f8c
Source dataset
uspto-grants-1979_08
Patent number
US04166072

Reaction notes

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