HCID 12733226, compound → HCID 20456968, compound

HRID 261496Notes

Reaction equation

HRID 261496 reaction equation
C(N1CCC2(CC3C=C([Cl:22])C=CC=3O2)CC1)C1C=CC=CC=1.Cl.C([N:31]1[CH2:36][CH2:35][C:34]2([CH2:40][C:39]3[CH:41]=[C:42]([Cl:45])[CH:43]=[CH:44][C:38]=3[O:37]2)[CH2:33][CH2:32]1)C1C=CC=CC=1>>[ClH:22].[Cl:45][C:42]1[CH:43]=[CH:44][C:38]2[O:37][C:34]3([CH2:33][CH2:32][NH:31][CH2:36][CH2:35]3)[CH2:40][C:39]=2[CH:41]=1

Participants

3

Reactant 2

HCID 12733226HCID 12733226, compoundHCID 20477805HCID 20477805, compound

Product 1

HCID 20456968HCID 20456968, compound

Procedure

A sample of 2,3-dihydro-1'-benzyl-5-chlorospiro[benzofuran-2,4'-piperidine], free base of Example 6, is treated in a manner consistent with the procedure of Example 9 to provide the product 2,3-dihydro-5-chlorospiro[benzofuran-2,4'-piperidine]hydrochloride, mp 217°-218° C. This product is obtained after three recrystallizations, two from ethyl alcohol and then one from an ethyl alcohol-ether mixture.

Sources & evidence

ORD record
ord-29c6d9644522414da1c8e68b88026b9e
Source dataset
uspto-grants-1979_08
Patent number
US04166119

Reaction notes

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