Sodium Bicarbonate → HCID 20394255, compound

Participants

Reaction Steps

A stirred suspension of 3.5 g of 2,3-dihydrospiro[benzofuran-2,4'-piperidine], Example 7 and 7.5 g of sodium bicarbonate in 40 ml of chloroform are reacted with a solution of 4.4 g of 4-methoxyphenylacetyl chloride in 10 ml of chloroform and thereafter treated according to the procedure of Example 13 to provide a yellow oil. The oil is chromatographed on a silica column with a 3% methyl alcohol in chloroform eluant to provide a white solid which is recrystallized thrice from hexane to provide the product, 2,3-dihydro-1'-[(4-methoxyphenyl)acetyl]spiro[benzofuran-2,4'-piperidine], mp 87°-88° C.

Provenance & Evidence