2-Furancarbonyl chloride → HCID 20394276, compound

HRID 261501Notes

Reaction equation

HRID 261501 reaction equation
[NH:1]1[CH2:6][CH2:5][C:4]2([CH2:10][C:9]3[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=3[O:7]2)[CH2:3][CH2:2]1.[O:15]1[CH:19]=[CH:18][CH:17]=[C:16]1[C:20](Cl)=[O:21]>>[O:15]1[CH:19]=[CH:18][CH:17]=[C:16]1[C:20]([N:1]1[CH2:6][CH2:5][C:4]2([CH2:10][C:9]3[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=3[O:7]2)[CH2:3][CH2:2]1)=[O:21]

Participants

3

Reactant 2

HCID 682422-Furancarbonyl chlorideHCID 127332303H-Spiro(1-benzofuran-2,4'-piperidine)

Product 1

HCID 20394276HCID 20394276, compound

Procedure

A sample of 5.8 g of 2,3-dihydrospiro[benzofuran-2,4'-piperidine], Example 7, is treated with 4.8 g of 2-furoyl chloride according to the procedure of Example 18 to provide an off-white solid. This solid is purified by three recrystallizations from hexane to provide the product, 2,3-dihydro-1'-(2-furoyl)spiro[benzofuran-2,4'-piperidine], mo 102°-103° C.

Workup

  1. customto provide an off-white solid
  2. customThis solid is purified by three recrystallizations from hexane

Sources & evidence

ORD record
ord-a68a2a3f0c1244b78e51cdbd3d612840
Source dataset
uspto-grants-1979_08
Patent number
US04166119

Reaction notes

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