Benzoyl chloride, 3,4,5-trimethoxy- → HCID 20394292, compound

Participants

Reaction Steps

A stirred mixture of 5.0 g of 2,3-dihydrospiro[benzofuran-2,4'-piperidine], Example 7, and 15 g of sodium bicarbonate in 75 ml of chloroform is treated with a mixture of 8.8 g of 3,4,5-trimethoxybenzoyl chloride in 125 ml of chloroform according to the procedure of Example 7 to provide a tan solid. The solid is sequentially recrystallized from ethyl alcohol, chromatographed through a silica gel column with a 2% methyl alcohol in chloroform eluant and recrystallized from ethyl alcohol to give the product, 2,3-dihydro-1'-(3,4,5-trimethoxybenzoyl)spiro[benzofuran-2,4'-piperidine], mp 148°-150° C.

Provenance & Evidence