HCID 20394272, compound → HCID 20394285, compound

Participants

Reaction Steps

A stirred suspension under nitrogen of 1.5 g of lithium aluminum hydride in 150 ml of tetrahydrofuran is treated with a solution of 2,3-dihydro-1'-(indol-3-ylglyoxyloyl)spiro[benzofuran-2,4'-piperidine], Example 22, in 75 ml of tetrahydrofuran according to the procedure of Example 22 to provide a tan solid. The solid is successively recrystallized from an ethyl alcohol-water mixture, chromatographed through a silica gel column with a 2% methyl alcohol in chloroform eluant and recrystallized from ethyl alcohol to provide the product, 2,3-dihydro-1'-[2-(3-indolyl)ethyl]spiro[benzofuran-2,4'-piperidine], mp 167°-169° C.

Provenance & Evidence