HCID 54463368, compound → HCID 12687084, compound

Participants

Reaction Steps

The mixture of 8.0 g of 2-chloro-6-(m-fluoro-phenylthio)-phenylacetic acid and 80 g at polyphosphoric acid was stirred at 120°-125° C. for 3 hours. After cooling, to the mixture was added water and the mixture was extracted with chloroform. The extract was washed with 100 ml of 1% sodium hydroxide solution, then water, dried over anhydrous sodium sulfate and freed of the solvent to afford 6.2 g (83%) of 3-fluoro-9-chloro-10,11-dihydrodibenzo[b,f]thiepin-11-one having a melting point of 109°-111° C.

Provenance & Evidence