Ethanol → 3-[(4-Chlorophenylsulfonyl)Methyl]-1,2,4-Oxadiazole-5-Carboxylic Acid Hydrazide

Participants

Reaction Steps

Five ml. of 95% hydrazine (.15 moles) in ethanol was added slowly, with stirring, to 3-[(4-chlorophenylsulfonyl)methyl]-1, 2,4-oxadiazole, 5-carboxylic acid ethyl ester suspended in ethanol at 5° C. This reaction mixture was stirred in ice for 5 hours and then overnight at room temperature. The product was filtered off and recrystallized from ethanol to give 8 g. of the product, with m.p. 177° C.

Provenance & Evidence