Diethylene Glycol → HCID 20394496, compound

Participants

Reaction Steps

A mixture of 1-ethoxycarbonyl-1,2,3,6-tetrahydro-2-[1-(4-chlorophenyl)-1-methylethyl]-4-methylpyridine (14.5 g), sodium hydroxide (15 g) and diethylene glycol (150 ml) was refluxed for 5 hours. After cooling, water was added to the reaction mixture and the resulting mixture was extracted with benzene. The extract was washed with water and dried over potassium carbonate. After removal of benzene, the residue was distilled under reduced pressure to obtain 10.7 g of a colorless viscous mass of 2-[1-(4-chlorophenyl)-1-methylethyl]-1,2,3,6-tetrahydro-4-methylpyridine.

Provenance & Evidence