Dicyclohexylcarbodiimide → HCID 70607463, compound

Participants

Reaction Steps

N,N'-Dibenzoyl lysine (140.4 g, 0.36 mol) dissolved in dioxan (350 ml) was added over 45 min to dicyclohexylcarbodiimide (88.0 g, 0.43 mol) in dioxan (193 ml). After stirring for 2 hours the mixture was set aside overnight, filtered from dicyclohexylurea (88.1 g), concentrated to half volume and added to H2O. The precipitate was collected and recrystallised from methylal to give 4-(4-benzamidobutyl)-2-phenyl-5-oxazolone (104 g, 86%) m.p. 118°-122°.

Provenance & Evidence