HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium thiocyanate → 4-(4-Benzamidobutyl)-5-methylimidazole-2-thione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium thiocyanate | HCID 516872 | — |
| Reactant | 3-Amino-7-benzamidoheptan-2-one hydrochloride | HCID 20394568 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-(4-Benzamidobutyl)-5-methylimidazole-2-thione | HCID 20394557 | 25.3% |
Reaction Steps
A solution of 3-amino-7-benzamidoheptan-2-one hydrochloride (16.39 g, 0.0576 mol) and potassium thiocyanate (7.30 g, 0.0755 mol, excess) in water was heated under reflux for 20 hours. The aquesus phase was decanted off and the organic phase was washed with water, and recrystallised from acetonitrile to give 4-(4-benzamidobutyl)-5-methylimidazole-2-thione (4.18 g, 25%) m.p. 180°-184°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04166184 |
| Source dataset | uspto-grants-1979_08 |
| ORD ID | ord-d1526fc277ce41089995dc0eceed56f5 |
| Source note | uspto-grants-1979_08 |