4-(4-methyl-1H-imidazol-5-yl)butan-1-amine → 1-Methylthio-1-[4-(5-methylimidazol-4-yl)butylamino]-2-nitroethylene

Participants

Reaction Steps

Reaction of 4-(4-aminobutyl)-5-methylimidazole (see Example 7 (ii), 0.765 g, 0.005 mol) with 1-methylsulphinyl-1-methylthio-2-nitroethylene(0.91 g, 0.005 mol), gave 1-methylthio-1-[4-(5-methylimidazol-4-yl)butylamino]-2-nitroethylene (0.69 g, 51%) which was treated directly with methylamine to yield 1-methylamino-b 1-[4-(5-methylimidazol-4-yl)butylamino]-2-nitroethylene (0.40 g, 61.9%). This compound was reacted with picric acid to give 1-methylamino-1-[4-(5-methylimidazol-4-yl)butylamino]-2-nitroethylene picrate hemihydrate (0.33 g, 26.3% last stage), m.p. 185°-187°.

Provenance & Evidence