Water → 2-Acetoxyamino-4-(3-trifluoromethylphenylcarbamoylmethyl)thiazole

Participants

Reaction Steps

To a solution of 5.0 g (0.017 mole) of 2-amino-4-(3-trifluoromethylphenylcarbamoylmethyl)thiazole in 22 ml of pyridine, there was added dropwise 2.8 g (0.03 mole) of methyl chloroformate. The solution was stirred and heated at 40°-45° for eighteen hours. The mixture was poured into 300 ml of cold water and stirring induced crystal formation. The solid was collected and the filter cake was washed with water. There was obtained 4.9 g of product, m.p. 137°-40°. N.M.R. (dimethyl-d6 sulfoxide) ∂ 3.6-3.9 (OCH3, CH2), 6.8 (hetero-aromatic), 7.3-8.1 (aromatic), 10.4 (HNC=0).

Provenance & Evidence