4-(5-Tert-butyl-1,3,4-thiadiazol-2-ylcarbamoylmethyl)-2-aminothiazole → 4-(5-Tert-butyl-1,3,4-thiadiazol-2-ylcarbamoylmethyl)-2-propionamidothiazole

Participants

Reaction Steps

A mixture of 4.8 g (0.016 mole) of 4-(5-tert-butyl-1,3,4-thiadiazol-2-ylcarbamoylmethyl)-2-aminothiazole dissolved 20 ml of propionic anhydride was heated for one hour at 90°. The reaction solution was cooled and the precipitate was collected. The crude solid was recrystallized from chloroform-hexane. There was obtained 1.9 g of product, m.p. 210°-12°. N.M.R. (CDCl3) ∂ 1.1-1.4 (CH3, triplet), 1.4 [C(CH3)3 ], 2.3-2.7 (CH2, quartet), 3.9 (CH2, singlet), 6.8 (hetero-aromatic).

Provenance & Evidence