HuagongsheHuagongshe Chemistry Print Report · For research reference only
UP 614-04 → 2-(1-Phenyl-2,3-dihydro-benzimidazol-2-on-3-yl-methyl)-morpholine maleate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | UP 614-04 | HCID 134375 | — |
| Reactant | Maleic Acid | HCID 444266 | — |
| Reactant | 4-Benzyl-2-(1-phenyl-2,3-dihydro-benzimidazol-2-on-3-yl-methyl)-morpholine | HCID 70601820 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 2-(1-Phenyl-2,3-dihydro-benzimidazol-2-on-3-yl-methyl)-morpholine maleate | HCID 86736083 | — |
Reaction Steps
18 g of 4-benzyl-2-(1-phenyl-2,3-dihydro-benzimidazol-2-on-3-yl-methyl)-morpholine are treated as in part (a) of Example 2. After evaporation of the solvent under reduced pressure, 15 g of an oily product are obtained and are dissolved in hot isopropyl alcohol. A hot solution of maleic acid in isopropanol is added. The salt precipitates slowly. 16.5 g of 2-(1-phenyl-2,3-dihydro-benzimidazol-2-on-3-yl-methyl)-morpholine maleate are obtained, m.p. 200° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04152434 |
| Source dataset | uspto-grants-1979_05 |
| ORD ID | ord-407ff9eee7264ce1a915aedfde839f02 |
| Source note | uspto-grants-1979_05 |