反应详情

温度

5 °C

16 g (0.1 mol) of bromine were added to a solution of 17.2 g (0.1 mol) of 1-methyl-2-methylthio-4-hydroxy-6-oxo-1,6-dihydro-pyrimidine in 110 ml of 1 N sodium hydroxide solution at room temperature. After the end of the addition, the batch was stirred for a further 0.5 hour and was then cooled to 5° C. The product which had precipitated was filtered off and rinsed with water. 18 g (76% of theory) of 1-methyl-2-methylthio-4-hydroxy-5-bromo-6-oxo-1,6-dihydro-pyrimidine were thus obtained in the form of pale yellow crystals of melting point 184° C. (with decomposition).

1. additionAfter the end of the addition
2. customThe product which had precipitated
3. filtrationwas filtered off
4. washrinsed with water