Methyl iodide → HCID 178504050, compound

HRID 261815Notes

Reaction equation

HRID 261815 reaction equation
[CH3:1][C:2]1[N:3]=[CH:4][NH:5][C:6]=1[CH2:7][S:8][CH2:9][CH2:10][NH:11][C:12]([NH2:14])=[S:13].[CH3:15][I:16]>CO>[I-:16].[CH3:15][S:13][C:12]([NH2:14])=[NH+:11][CH2:10][CH2:9][S:8][CH2:7][C:6]1[NH:5][CH:4]=[N:3][C:2]=1[CH3:1]

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 178433321HCID 178433321, compound

Product 1

HCID 178504050HCID 178504050, compoundYield 62.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of N-[2-((4-methyl-5-imidazolyl)methylthio)ethylthiourea (2.29 g.) and methyl iodide (1.56 g.) in methanol (5 ml) was kept at room temperature for 18 hours affording S-methyl-N-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]thiouronium iodide (2.3g.), m.p. 128°-131°. The iodide was concentrated to the corresponding sulphate by ion-exchange on an ion-exchange resin (IRA 401) in the sulphate form.

Sources & evidence

ORD record
ord-26304a4014ac4ccfb401016425137ff9
Source dataset
uspto-grants-1979_05
Patent number
US04152443

Reaction notes

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