HRID26184

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7918

Acetic anhydride

C4H6O3

结构：CC(=O)C(Cc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1)(Cc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1)C(=O)OC1CC(C)(C)NC(C)(C)C1

HCID23338166

未命名化合物

PRODUCTS

生成物

结构：CC(=O)N1C(C)(C)CC(OC(=O)C(Cc2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2)(Cc2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2)C(C)=O)CC1(C)C

HCID23338188

未命名化合物

PROCEDURE

实验过程

A solution of 2,2,6,6-tetramethyl-4-piperidinyl 2,2-bis-(3,5-di-tert-butyl-4-hydroxybenzyl)-acetoacetate (Example 1, 10.0 g; 0.015 mol) in 100 ml of acetic anhydride is stirred for 20 hours at 100°. The mixture is concentrated in vacuo. After recrystallisation from hexane/toluene, the product is filtered off and 8.41 g of 1-acetyl-2,2,6,6-tetramethyl-4-piperidinyl 2,2-bis-(3,5-di-tert-butyl-4-hydroxybenzyl)-acetoacetate, melting point 165°-166° C. (compound 22), are obtained.

WORKUP

后处理

concentrationThe mixture is concentrated in vacuo
customAfter recrystallisation from hexane/toluene
filtrationthe product is filtered off

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-87efbb3cd2e2408bab3720b01796182a
来源数据集: uspto-grants-1979_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04148784
来源说明: uspto-grants-1979_04

反应 SMILES

[C:1]([C:5]1[CH:6]=[C:7]([CH:42]=[C:43]([C:46]([CH3:49])([CH3:48])[CH3:47])[C:44]=1[OH:45])[CH2:8][C:9]([CH2:26][C:27]1[CH:32]=[C:31]([C:33]([CH3:36])([CH3:35])[CH3:34])[C:30]([OH:37])=[C:29]([C:38]([CH3:41])([CH3:40])[CH3:39])[CH:28]=1)([C:23]([CH3:25])=[O:24])[C:10]([O:12][CH:13]1[CH2:18][C:17]([CH3:20])([CH3:19])[NH:16][C:15]([CH3:22])([CH3:21])[CH2:14]1)=[O:11])([CH3:4])([CH3:3])[CH3:2].[C:50](OC(=O)C)(=[O:52])[CH3:51]>>[C:33]([C:31]1[CH:32]=[C:27]([CH:28]=[C:29]([C:38]([CH3:41])([CH3:40])[CH3:39])[C:30]=1[OH:37])[CH2:26][C:9]([CH2:8][C:7]1[CH:42]=[C:43]([C:46]([CH3:49])([CH3:48])[CH3:47])[C:44]([OH:45])=[C:5]([C:1]([CH3:2])([CH3:3])[CH3:4])[CH:6]=1)([C:23]([CH3:25])=[O:24])[C:10]([O:12][CH:13]1[CH2:14][C:15]([CH3:22])([CH3:21])[N:16]([C:50](=[O:52])[CH3:51])[C:17]([CH3:20])([CH3:19])[CH2:18]1)=[O:11])([CH3:36])([CH3:35])[CH3:34]