反应详情

Methylisocyanate (1.96 milliliters, 0.04 mole) was added dropwise to a thirty (30) milliliter solution of the distilled tetrahydrofuran containing the above mentioned 5-amino-3-methylisothiazole (5.0 grams, 0.04 mole), and then the resulting yellow solution was refluxed for 3 hours, during which time a white precipitate formed. The solution was cooled and filtered, giving 3.73 grams of N-(3-methyl-5-isothiazolyl)-N'-methylurea, also referred to as 3-methyl-5-N-methylureiodisothiazole.

1. temperaturethe resulting yellow solution was refluxed for 3 hours, during which time a white precipitate
2. customformed
3. temperatureThe solution was cooled
4. filtrationfiltered