HCID 13101053, compound → HCID 13101052, compound

Participants

Reaction Steps

Starting with 1030 g. (2.61 moles) of 4-chloro-N-[4-(diethylamino)-1-methylbutyl]-2-nitrothiobenzamide hydrochloride, the above procedure was repeated except that after the addition was complete the reaction mixture was stirred 4.5 hours without cooling; then treated with 150 ml. of n-octanol and stirred overnight at room temperature. The product was isolated as described above to give 715 g. of 6-chloro-3-[4-(diethylamino)-1-methylbutylamino]-2,1-benzisothiazole. A similar run starting with 3,360 g. (8.52 moles) of 4-chloro-N-[4-(diethylamino)-1-methylbutyl]-2-nitrothiobenzamide produced 1,915 g. of product.

Provenance & Evidence