HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → (4-chlorophenyl)(1H-imidazol-2-yl)phenylmethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-[(Benzyloxy)methyl]-alpha-(p-chlorophenyl)-alpha-phenylimidazole-2-methanol | HCID 12433915 | — |
| Solvent | Water | HCID 962 | — |
| Product | (4-chlorophenyl)(1H-imidazol-2-yl)phenylmethanol | HCID 12433863 | — |
Reaction Steps
About 17 g. (0.042 mol) of 1-[(benzyloxy)methyl]-α-(p-chlorophenyl)-α-phenylimidazole-2-methanol was boiled under reflux in a mixture of 85 ml. of glacial acetic acid, 8.5 ml. of water and 8.5 ml. of concentrated hydrochloric acid solution. Acetic acid was removed by evaporation and the base was liberated by addition of 2 N sodium hydroxide solution. It was crystallised from isopropyl alcohol. Melting point of the product was 162°-165° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04152441 |
| Source dataset | uspto-grants-1979_05 |
| ORD ID | ord-cceeaee25d9846e69e81e02792f0e7c9 |
| Source note | uspto-grants-1979_05 |