2-Nitrophenol → HCID 20446322, compound

HRID 262015Notes

Reaction equation

Br[CH:2]1[CH2:4][CH2:3]1.[N+:5]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[OH:14])([O-:7])=[O:6]>>[CH:2]1([O:14][C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[N+:5]([O-:7])=[O:6])[CH2:4][CH2:3]1

Participants

Reactant 2

HCID 69472-Nitrophenol

HCID 78037Bromocyclopropane

Product 1

HCID 20446322HCID 20446322, compound

Procedure

In a similar manner as in Example 1, bromocyclopropane was reacted with o-nitrophenol to yield 2-cyclopropoxynitrobenzene; which was reduced to the corresponding aniline; reacted with N-methylolpyrrolidone to form the corresponding N-methylenepyrrolidonyl derivative; and acetylated with chloroacetyl chloride to form the desired product.

Sources & evidence

ORD record: ord-504205bbf4aa40259d8d7719f8036f15
Source dataset: uspto-grants-1979_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04153446

Reaction notes

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