2-Nitrophenol → HCID 21319716, compound

HRID 262016Notes

Reaction equation

HRID 262016 reaction equation
Br[CH:2]1[CH2:5][CH2:4][CH2:3]1.[N+:6]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[OH:15])([O-:8])=[O:7]>>[CH:2]1([O:15][C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[N+:6]([O-:8])=[O:7])[CH2:5][CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 69472-NitrophenolHCID 78110Bromocyclobutane

Product 1

HCID 21319716HCID 21319716, compound

Procedure

In a similar manner as in Example 1, bromocyclobutane was reacted with o-nitrophenol to yield 2-cyclobutoxynitrobenzene; which was reduced to the corresponding aniline; reacted with N-methylolpyrrolidone to form the corresponding N-methylenepyrrolidonyl derivative; which was acylated with chloroacetyl chloride to form the desired product.

Sources & evidence

ORD record
ord-c6c9cef10fec4faa85adf2cc7cfb7a76
Source dataset
uspto-grants-1979_05
Patent number
US04153446

Reaction notes

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