Iodine → HCID 70610342, compound

HRID 262086Notes

Reaction equation

HRID 262086 reaction equation
[C:1]1([C:7]2[CH:15]=[C:11]3[CH:12]=[CH:13][CH:14]=[C:10]3[O:9][C:8]=2[CH2:16][C:17]([OH:19])=[O:18])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[I:20]I>C1C=CC=CC=1>[I:20][C:8]1([CH2:16][C:17]([OH:19])=[O:18])[CH:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH:15]=[C:11]2[CH:12]=[CH:13][CH:14]=[C:10]2[O:9]1

Participants

4

Reactant 2

HCID 807IodineHCID 70609976HCID 70609976, compound

Product 1

HCID 70610342HCID 70610342, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

To a solution of 2.08 g. (8.25 mmoles) of 3-phenyl-7-benzofuranacetic acid in 10 ml. of benzene at 60° C. is slowly added small portions of yellow mercuric oxide (1.45 g., 6.7 mmoles) and iodine (2.09 g., 8.25 mmoles). After about two hours the mixture is filtered, then the filtrate is evaporated to dryness to provide 2-iodo-3-phenyl-7-benzofuranacetic acid.

Workup

  1. customat 60° C.
  2. filtrationAfter about two hours the mixture is filtered
  3. customthe filtrate is evaporated to dryness

Sources & evidence

ORD record
ord-0dd2171892494f17a0b5c28c47231ba9
Source dataset
uspto-grants-1979_05
Patent number
US04153619

Reaction notes

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