HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 7-Bromo-5-methyl-3-phenylbenzofuran
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 2-(2-Bromo-4-methylphenoxy)acetophenone | HCID 4077236 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 7-Bromo-5-methyl-3-phenylbenzofuran | HCID 21319928 | — |
Reaction Steps
A mixture of 700 g. of polyphosphoric acid and 100 g. of α-(2-bromo-4-methylphenoxy)acetophenone is heated at 80°-90° C. for two hours, then poured into two liters of water with stirring. Chloroform (1 liter) is added, and the phases are separated. The organic layer is washed with water, dried, then evaporated to provide 7-bromo-5-methyl-3-phenylbenzofuran as a brown oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04153619 |
| Source dataset | uspto-grants-1979_05 |
| ORD ID | ord-8e550f305de947eaa87715bf888aacd9 |
| Source note | uspto-grants-1979_05 |